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Unlike iMQT_020, V-9302 inhibited the mitochondrial uptake of leucine, asparagine, and serine (Fig

All experiments were performed between 48 h and 72 h after transfection

Overall, this research provides important insights into the interactions between antimalarial agents and Pf GR and encourages further exploration of its role in the mechanisms of action of antimalarials, including dual drugs, to enhance antiparasitic efficacy

4 C,E ), consistent with the glutathione cycle being able to compensate for decreased availability of glutamine, an established source of glutamate neurotransmitter

Research in the Gilkes Lab is funded by The Jayne Koskinas Ted Giovanis Foundation for Health and Policy and the NCI/SKCCC Core grant number P50CA006973 (D.G.)

In Vitro Pyocyanin (5, 10 M, 24 h) has an anti-inflammatory effect on mouse peritoneal macrophages, down-regulating levels of nitric oxide, TNF- and IL-1 [2]